狨猴脑图谱V3：群体多模式标准容积和基于表面的模板

标准解剖学脑模板为可视化和分析来自大群受试者的神经影像数据提供了一个共同的空间和坐标系统。以前的普通狨猴大脑模板和图谱要么是基于单个个体的数据，要么缺乏神经影像分析的基本功能。在此，我们提出了新的基于群体的体内标准模板和工具，这些模板和工具来自27只狨猴的多模式数据，包括多种类型的T1w和T2w对比图像，DTI对比，以及大视野的MRI和CT图像。我们在新模板上进行了解剖结构的多图谱标记，并构建了高度精确的组织类型分割图，以促进体积研究。我们构建了功能齐全的大脑表面和皮质平面图，以促进三维可视化和基于表面的分析，这与大多数表面分析工具兼容，包括FreeSurfer、AFNI/SUMA和Connectome Workbench。对MRI和CT数据集的分析显示，大脑形状、大小和大脑结构的区域体积有很大的变化，突出了狨猴群体中大量的个体差异性。因此，我们基于群体的模板和相关工具为广泛的磁共振成像和普通狨猴的连接组研究提供了一个多功能的分析平台和标准坐标系统。这些新的模板工具包括我们的狨猴脑图谱项目的第三版，可通过marmosetbrainmapping.org/v3.html公开获得。

Standard anatomical brain templates provide a common spatial and coordinate system for visualizing and analyzing neuroimaging data from large cohorts of subjects. Prior common marmoset brain templates and atlases were either based on data from a single individual or lacked core functionalities for neuroimaging analysis. Here, we present novel population-based in vivo standard templates and tools derived from multimodal data from 27 marmosets, including multiple types of T1-weighted (T1w) and T2-weighted (T2w) contrast images, diffusion tensor imaging (DTI) contrasts, as well as large-field-of-view MRI and CT images. We performed multi-atlas labeling of anatomical structures on the new templates and constructed highly accurate tissue-type segmentation maps to facilitate volumetric studies. We developed fully functional brain surface and cortical flat maps to enable 3D visualization and surface-based analysis, which are compatible with most surface analysis tools including FreeSurfer, AFNI/SUMA, and the Connectome Workbench. Analysis of the MRI and CT datasets revealed substantial variation in brain shape, size, and regional volumes of brain structures, highlighting significant individual variability within the common marmoset population. Accordingly, our population-based templates and associated tools provide a versatile analytical platform and standard coordinate system for a wide range of magnetic resonance imaging and connectomics studies in common marmosets. These novel template tools include the third edition of our marmoset brain atlas project, which is publicly available at marmosetbrainmapping.org/v3.html.

搜集汇总

背景与挑战

背景概述

狨猴脑图谱V3是一个基于27只狨猴多模态数据的群体标准模板，包含多种MRI和CT图像，支持神经影像分析和3D可视化。该数据集提供了详细的解剖结构标记和组织类型分割，适用于广泛的MRI和连接组研究。