Cell surface proteome profiling of cancer-associated fibroblast-induced myeloid-derived suppressor cells and related cell types

Cancer-associated fibroblasts (CAF) promote immune suppression in the tumor microenvironment by polarizing monocytes to myeloid-derived suppressor cells (MDSC) that potently suppress T-cell function. Using a patient-derived coculture system, we profiled the cell surface proteome of CAF-induced MDSC to identify potential mechanism through which T-cell function is impaired.