Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1259207775 (A71EV2A-x0556)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1259207775 (A71EV2A-x0556) Descriptor: 4-amino-N-cyclobutyl-1-methyl-1H-pyrazole-3-carboxamide, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16（G-10株）2A蛋白酶晶体学片段筛选数据集联合提交——柯萨奇病毒A16（G-10株）2A蛋白酶与Z1259207775（A71EV2A-x0556）复合物的晶体结构 配体描述：4-氨基-N-环丁基-1-甲基-1H-吡唑-3-甲酰胺、二甲基亚砜、2A蛋白酶等 作者：Lithgo, R.M、Fairhead, M、Koekemoer, L、Balcomb, B.H、Capkin, E、Chandran, A.V、Golding, M、Godoy, A.S、Aschenbrenner, J.C、Marples, P.G、Ni, X、Thompson, W、Tomlinson, C.W.E、Wild, C、Winokan, M、Xavier, M.-A.E、Fearon, D、von Delft, F 提交日期：2024-04-04 发布日期：2024-04-24 最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率1.32埃） 引用文献：《针对柯萨奇病毒A16 2A蛋白酶的晶体学片段筛选为广谱抗肠病毒药物开发提供新机遇》，bioRxiv，2024