Danio rerio Transcriptome or Gene expression. Danio rerio

The liver is critical in alcohol metabolism, and excessive consumption heightens the risk of hepatic damage, potentially escalating to hepatitis and cirrhosis. Jiuzao, a by-product of Baijiu production, contains a rich concentration of naturally active polysaccharides known for their antioxidative properties. This study investigated the influence of Jiuzao polysaccharide (LWZ) on the development of ethanol-induced alcoholic fatty liver. The study evaluated LWZ's effects on gene expression associated with alcoholic fatty liver. Transcriptomic data indicated that LWZ ameliorates hepatic fat accumulation and liver injury by enhancing gene expression involved in ethanol and lipid metabolism. Ultimately, LWZ mitigates alcohol-induced hepatic injury by modulating gene expression related to ethanol metabolism, lipid metabolism, and inflammation.