HLA-association to transformed JCV nOD levels in German MS patients.

Results from the linear regression analysis of the association between HLA-alleles and JCV nOD levels. Only alleles that are nominally significant (ptable 4 are presented. P-values that reach nominal significance, 0.05 are marked in bold. The median nOD levels are given among individuals positive or negative for respective HLA allele. Each allele was analysed on its own, adjusted for age at sampling, significant principal components from EIGENSTRAT analysis of genomewide SNP data and gender. Age was included as a continuous covariate. The analysis was carried out in PLINK 1.07 [49]. As only alleles on the DQB1*06:02-DQA1*01:02-DRB1*15 haplotype were significant no multivariate analysis was performed. * Median nOD is given among individuals positive or negative for respective HLA allele.Common extended HLA haplotypes were selected from those published in the literature for the Caucasian population [19]–[21]. Alternative common DRB1*15 haplotypes DQB1*06:02-DQA1*01:02-DRB1*15-B*07-C*07-A*02, DQB1*06:02-DQA1*01:02-DRB1*15-B*07-C*07-A*03, DQB1*06:02-DQA1*01:02-DRB1*15-B*51-C*?-A*02, DQB1*06:02-DQA1*01:02-DRB1*15-B*51-C*?-A*11. The DQB1*03:01-DQA1*05-DRB1*11-B*51-A*02 haplotype exist with many different C alleles, C*05 not being the most common one.