Cdkn2a

ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase inhibitor activity (ortholog); disordered domain specific binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN cellular response to glucose stimulus; cerebellum development; negative regulation of hepatocyte proliferation; PARTICIPATES IN altered G1/S transition pathway; G1/S transition pathway; pancreatic cancer pathway; ASSOCIATED WITH increased mesothelioma incidence; ASSOCIATED WITH Colonic Neoplasms; endometrial cancer; Esophageal Neoplasms; FOUND IN cytoplasm (ortholog); granular component (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine

编码一种表现出周期依赖性蛋白丝氨酸/苏氨酸激酶抑制活性（同源物）；无序结构域特异性结合（同源物）；DNA结合转录因子结合（同源物）；参与细胞对葡萄糖刺激的应答；小脑发育；抑制肝细胞增殖的负调节；参与G1/S转换途径的调节；G1/S转换途径；胰腺癌途径；与间皮瘤发病率增加相关；与结肠肿瘤相关；与子宫内膜癌相关；与食管肿瘤相关；存在于细胞质中（同源物）；存在于颗粒成分中（同源物）；存在于线粒体中（同源物）；与（+）毛果芸香碱、17β-雌二醇、2,3,7,8-四氯二苯并-对-二恶英相互作用。