Parental cardiorespiratory fitness influences early life energetics and metabolic health

Introduction. High cardiorespiratory fitness (CRF) is associated with a reduced risk for metabolic disease across the life course. Evidence suggests this may partly be due to superior mitochondrial respiratory function. Objective. To determine the impact of intrinsic CRF on bioenergetics and metabolic health in adulthood and early life. Methods. Adult rats selectively bred for low (low-capacity runners, LCR) and high (high-capacity runners, HCR) running capacity were metabolically phenotyped prior to being mated. Thereafter, LCR and HCR weanlings were studied at 4-6 weeks of age. Microbial abundance of weanlings' colon content was evaluated by 16S rRNA sequencing.

引言。高心肺功能（CRF）与生命周期中代谢疾病风险降低相关。证据表明，这可能与优异的线粒体呼吸功能部分相关。研究目标。旨在确定内在心肺功能对成年期及早期生命过程中的生物能量学和代谢健康的影响。研究方法。对低（低容量跑者，LCR）和高（高容量跑者，HCR）运动能力的大鼠进行代谢表型分析，并在交配前进行。此后，对LCR和HCR断奶幼鼠在4-6周龄时进行研究。通过16S rRNA测序评估断奶幼鼠结肠内容物的微生物丰度。