Genes that are either enriched or depleted in the NCI-60), and are cancer-driver genesa.

aGenes selected from the boxed fractions from Figure 3A. Cancer-driver genes are as described previosly [58].bOfficial gene names as defined by the HUGO Gene Nomenclature Committee (http://www.genenames.org/).cDDR is DNA damage response, and SLC is solute carrier.dAmino acid impact. Example, R116Q indicates a change from R (Arg, arginine) to Q (Gln, glutamine).dDenotes the chromosome number, start location, and the nucleotide change. _* indicates that either an addition (+) or a deletion (−) of nucleotides.eSingle nucleotide polymorphisms identifiers as defined at dbSNP (http://www.ncbi.nlm.nih.gov/projects/SNP/).fFrequency calculated as described in Materials and Methods.