Treatment of Atypical Teratoid/Rhabdoid Tumors (AT/RT) of the Central Nervous System With Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation

This phase III trial studies the side effects of combination chemotherapy, 3-dimensional
conformal radiation therapy, and an autologous peripheral blood stem cell transplant, and to
see how well they work in treating young patients with atypical teratoid/rhabdoid tumor of
the central nervous system. Giving high-dose chemotherapy before an autologous peripheral
blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or
killing them. Giving colony-stimulating factors, such as G-CSF, helps stem cells move from
the bone marrow to the blood so they can be collected and stored. Chemotherapy or radiation
therapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells
are then returned to the patient to replace the blood-forming cells that were destroyed by
the chemotherapy or radiation therapy.