STING facilitates vascular calcification via p-STAT1/NLRP3 signal

Vascular calcification contributes to the cardiovascular morbidity and mortality of chronic kidney disease (CKD), but there is no approved treatment for vascular calcification. In this study, we report the role of STING in vascular calcification. To further investigate the molecular mechanism by which STING participates in vascular calcification, we performed high-throughput RNA-seq to identify the target gene of STING. Overall design: Primary mouse vascular smooth muscle cells from wild type and STING-/- mice were cultured in calcifying medium (CM). RNA-seq was performed to determine the downstream target of STING.