Summary of association of use of individual drugs with treatment success.

Bold, estimates are significantly different from the reference group.an shown, the number of patients that received the drug in question and were included in the specific analysis.baOR for use of drug, with non-use as the reference category. Adjusted for age, sex, HIV, past TB treatment, past MDR treatment (treatment for more than 1 mo with two or more second-line drugs), and extent of disease. Missing information was imputed for the following parameters in the following number of patients: Sex was missing in three, age was missing in 27, HIV was missing in 1,271 (14%), history of past TB treatment missing in 443 (5%), history of past second-line drug use 758 (8%), and extent of disease information missing in 174 (2%).cVariance of the random intercepts and slopes low, so heterogeneity not likely to be important.dVariance of the random intercepts and slopes could not be estimated.eVariance of the random intercepts and slopes high, so heterogeneity likely important.fGroup 5 individual drugs: Analysis restricted to patients who received only one group 5 drug. Each single drug comparison made between patients who received only that group 5 agent with patients who received any other single group 5 drug. Drugs included in this analysis as group 5 drugs were: amoxicillin-clavulanate, macrolides (azithromycin, roxithromycin, and clarithromycin), clofazimine, thiacetazone, imipenem, linezolid, high dose INH, and thioridazine. Later generation quinolones included levofloxacin, moxifloxacin, gatifloxacin, and sparfloxacin. Cycloserine included terizidone—a dimer of D-cycloserine given in some centers.