Data from: Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer’s disease

Vascular abnormalities may contribute to amyloid-beta accumulation and
neurotoxicity in Alzheimer’s disease (AD). Monitoring vascular
degeneration as AD progresses is essential. Three-photon fluorescence
microscopy (3PM) enables high-resolution deep tissue imaging with minimal
invasiveness and photodamage. We demonstrated the potential of
three-photon imaging to track vascular and amyloid-related changes in deep
cortical structures. It offers a tool for studying the interplay between
vascular and amyloid pathologies in AD, supporting future research into
disease mechanisms and therapeutic strategies. This dataset contains all
three-photon imaging data used in the manuscript, including plaques and
vascular structures across multiple mice, fields of view (FOVs), and two
longitudinal imaging sessions. GFP labeled neurons with vessels as well as
neonatal lung imaging for power calibration can also be found in the
folder.