Palbociclib-resistant cell sequencing

NIAID Data Ecosystem2026-05-02 收录

CDK4/6抑制剂耐药性

乳腺癌细胞系测序

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1144658 数据链接链接失效反馈

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palbociclib-resistant (PR) cell line was generated by culturing each of the MCF-7 cell pools in complete medium supplemented with palbociclib for 96 hours. This is the control group and drug resistance group sequencing results.

创建时间：

2024-08-06

HDAC5 loss impairs RB repression of oncogenic related genes and confers CDK4/6 inhibitor resistance in cancer [RNA-seq]

CDK4/6抑制剂耐药性

前列腺癌治疗

The tumor suppressor protein RB acts as a transcription repressor via the interaction of its pocket domain with an L/IXCXE motif in HDAC proteins such as HDAC1. Here we demonstrated that while lacking

NIAID Data Ecosystem60

Activation of the interferon signaling pathway is associated with resistance to CDK4/6 inhibitors and immune checkpoint activation in ER-positive breast cancer [RNA-seq]. Activation of the interferon signaling pathway is associated with resistance to CDK4/6 inhibitors and immune checkpoint activation in ER-positive breast cancer [RNA-seq]

CDK4/6抑制剂耐药性

干扰素信号通路与乳腺癌耐药

CDK4/6 inhibitors are highly effective against ER+/HER2- breast cancer (BC); however, intrinsic and acquired resistance is common. Elucidating the molecular features of sensitivity and resistance to C

NIAID Data Ecosystem50

CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas

甲状腺癌靶向治疗

CDK4/6抑制剂耐药性

Despite overall good prognosis associated to thyroid cancer, poorly differentiated carcinomas (PDTC) and anaplastic carcinomas (ATC) represent major clinical challenges. We have shown that the presenc

NIAID Data Ecosystem40

Table_3_CDK4/6 inhibitor resistance: A bibliometric analysis.xlsx

CDK4/6抑制剂耐药性

文献计量学

BackgroundCyclin-dependent kinases (CDKs) 4/6 inhibitors are a type of cell cycle regulation that prevents cell proliferation by blocking retinoblastoma protein (Rb) phosphorylation in the G1 to S pha

NIAID Data Ecosystem50

MicroRNA-mediated suppression of the TGF-Ã pathway confers transmissible and reversible CDK4/6 inhibitor resistance (miRNA-Seq)

CDK4/6抑制剂耐药性

乳腺癌miRNA

CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptor (ER)-positive breast cancer, so that defining mechanisms of resistance is a pressing issue. Here, we ide

NIAID Data Ecosystem40

Palbociclib-resistant cell sequencing

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