Triggers of Thyroid Cancer Diagnosis

this is a supplement of A Systematic Review and Meta-analysis. The incidence of thyroid cancer has increased worldwide. In the United States, for instance, the incidence of thyroid cancer increased from a 4.9 to 14.2 per 100,000 person-years over the last two decades, while in South Korea, on the other hand, thyroid cancer increased by more than seven fold, from 6.3 per 100,000 person year in 1999 to 47.5 per 100,000 population in 2009. Understanding the method of thyroid cancer detection has potential implications on interpreting incidence rates, the diagnosis and management of thyroid cancer. The aim of this study is to summarize the available evidence to assess the frequency of incidental (asymptomatic) and non-incidental TC and examine the triggers that lead to diagnosis with comparison across multiple cohorts.