Gene expression profiles in the lung following intratracheal instillation of cellulose nanofibrils and multi-walled carbon nanotubes in a murine COPD model. Gene expression profiles in the lung following intratracheal instillation of cellulose nanofibrils and multi-walled carbon nanotubes in a murine COPD model

To evaluate the transcriptional-level biological effects of manufactured nanomaterials, a whole-genome microarray analysis was performed on the lungs of a murine chronic obstructive pulmonary disease (COPD) model. Mice were intratracheally instilled with cellulose nanofibrils (CNFs) or multi-walled carbon nanotubes (MWCNTs). Overall design: Mice were intratracheally instilled with CNFs, MWCNTs (80µg/mouse), or vehicle solutions (Control). Lungs were excised 28 days post-instillation for microarray analysis.