(4+1) vs (4+2): Catalytic Intramolecular Coupling between Cyclobutanones and Trisubstituted Allenes via C–C Activation
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/_4_1_vs_4_2_Catalytic_Intramolecular_Coupling_between_Cyclobutanones_and_Trisubstituted_Allenes_via_C_C_Activation/2117245
下载链接
链接失效反馈官方服务：
资源简介：
Herein
we describe a rhodium-catalyzed (4+1) cyclization between
cyclobutanones and allenes, which provides a distinct [4.2.1]-bicyclic
skeleton containing two quaternary carbon centers. The reaction involves
C–C activation of cyclobutanones and employs allenes as a one-carbon
unit. A variety of functional groups can be tolerated, and a diverse
range of polycyclic scaffolds can be accessed. Excellent enantioselectivity
can be obtained, which is enabled by a TADDOL-derived phosphoramidite
ligand. The bridged bicyclic products can be further functionalized
or derivatized though simple transformations.
创建时间：
2016-02-12
