Sequencing of the Gut Microbiome in a Mouse Model of Depression

Depression is increasingly linked to inflammation, yet its underlying mechanisms remain only partially understood. In this study, SDV was performed to evaluate its effects on behavioral, immunological, and microbiological parameters. Two weeks after SDV, mice were administered LPS or saline, and their behaviors were assessed using the open field and forced swimming tests. Gut microbiota analysis further demonstrated that SDV restored LPS induced changes in bacterial diversity and composition.