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EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

ChEBI2013-05-13 更新2026-07-21 收录

淋巴瘤表观遗传学

EZH2基因突变分析

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-45982 数据链接链接失效反馈

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资源简介：

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

应用场景：

创建时间：

2013-05-13

淋巴瘤表观遗传学

DNA甲基化特征

We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differenc

NIAID Data Ecosystem80

H3K5me3 modifications in OCI-LY19 cells with and without SETD1B mutations.

淋巴瘤表观遗传学

药物耐药性

The translocation t(14;18) activates BCL2 and is considered the initiating genetic lesion in most follicular lymphomas (FL). Surprisingly, FL patients fail to respond to the BCL2 inhibitor, Venetoclax

NIAID Data Ecosystem40

Epigenetic Activation of SOX11 in Lymphoid Neoplasms by Histone Modifications

淋巴瘤表观遗传学

组蛋白修饰

Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive

Figshare2016-01-18 更新10

Methylation and gene expression data obtained from Dnmt3b+/+, Dnmt3bD/D and Dnmt3bCI/CI MYC induced T-cell lymphomas (MTCLs).. Methylation and gene expression data obtained from Dnmt3b+/+, Dnmt3bD/D and Dnmt3bCI/CI MYC induced T-cell lymphomas (MTCLs).

淋巴瘤表观遗传学

甲基化功能研究

DNA methylation has suppressive effects on gene transcription and it is involved in a variety of physiologic processes, including development and cancer. As we and others demonstrated, Dnmt3b is a tum

NIAID Data Ecosystem60

Classical Hodgkin lymphoma shows epigenetic features of an abortive plasma cellular differentiation: expression of PCM vs. B-cell lines

淋巴瘤表观遗传学

细胞分化异常

Classical Hodgkin lymphoma shows epigenetic features of an abortive plasma cellular differentiation: expression of PCM vs. B-cell lines

ChEBI2011-05-05 更新20