AUC, accuracy, sensitivity, specificity, predictive values, likelihood ratios of baseline liver histology, HVPG and non-invasive fibrosis biomarkers to predict clinical outcomes.

Legend: HVPG, hepatic venous pressure gradient; APRI, AST-to-Platelet Ratio; NAFLD, nonalcoholic fatty liver; AUC, area under the curve; SE, standard error; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio. Accuracy, sensitivity, specificity, PPV, NPV and LR are computed based on the cut-off values adopted in the multivariate analysis: histologic fibrosis F3-F4, HVPG>10, APRI≥1.5, FIB-4>3.25, NAFLD fibrosis score>0.676.AUC, accuracy, sensitivity, specificity, predictive values, likelihood ratios of baseline liver histology, HVPG and non-invasive fibrosis biomarkers to predict clinical outcomes.