Expression of PAX7 in the neural plate border

PAX7 is expressed in lateral and posterior regions of the neural plate border after expression of MSX1, TFAP2A, and DLX5 have initiated (Khuyakov et al. 2009, Williams et al. 2022). Expression continues in the neural folds (Basch et al. 2006, Khudyakov et al. 2009). The TFAP2A:TFAP2C heterodimer (Rothstein and Simoes-Costa 2020) and MYB (Vadasz et al. 2013) bind the PAX7 gene and activate its expression in the neural plate border. FGF4 can also activate PAX7 expression in extra-embryonic ectodermal cells (Yardley and Garcia-Castro 2012).

PAX7基因在MSX1、TFAP2A及DLX5表达启动之后，于神经板边缘的侧后区域被表达（Khuyakov等，2009，Williams等，2022）。其表达持续于神经褶（Basch等，2006，Khudyakov等，2009）。TFAP2A:TFAP2C异源二聚体（Rothstein和Simoes-Costa，2020）及MYB（Vadasz等，2013）结合PAX7基因，并激活其在神经板边缘的表达。此外，FGF4也能在胚胎外胚层细胞中激活PAX7的表达（Yardley和Garcia-Castro，2012）。