EPI-Clone dataset: Human CD34+ cells (A.1-A.7, B.1-B.5)

This is the dataset supporting the EPI-Clone manuscript: Targeted single cell methylation profiling of bone marrow was performed with the scTAMseq method. BM from seven donors was analyzed Donor characteristics are described in full in Table S1. This seurat object includes CD34+ cells from all donors A.1-A.7, B.1-B.5. For EPI-Clone analysis, only donors with >1000 CD34+ cells covered were included.Dataset is an R Data File (RDS) with an integrated Seurat object across donorsASSAYS:AB: Antibody expression dataDNAm: DNA methylation data, containing binary observations (0: amplicon not observed, i.e. dropout or absence of DNA methylation, 1: amplicon observed, i.e. DNA methylation). See the paper on scTAMseqDIMENSIONALITY REDUCTIONscanorama: scanorama performed on the DNAm+AB dataumap: UMAP computed on scanoramaTo create donor-specific static CpGs UMAPs, follow the vignette at https://github.com/veltenlab/EPI-cloneMETADATAsample: Donor (A.1 - A.7)age: Donor agecelltype: Cell type annotationNonHhaI: Performance of the control amplicons in that celllog_ChrY: Log number of reads on the ChromosomeY ampliconsEPIClone_id: Cluster annotation computed by EPI-Clonemutation: CH mutation called in each cell. N/A means dropout.