BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (RNA-seq). BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (RNA-seq)

We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells. Overall design: RNA-seq analysis of 20 samples: Activated CD8 T cells (n=5); Activated c-Myc KO CD8 T cells (n=5); First-division WT CD8 T cells (n=5); First division Arid1a KO CD8 T cells (n=5)