IL10 gene produces IL10 protein

The Interleukin 10 (IL10) gene is located at chromosome 1q31-32. It encodes for a protein with the same name that acts as a pleiotropic cytokine expressed primarily by monocytes and to a smaller degree by lymphocytes. IL10 down-regulates the expression of Th1 cytokines, MHC class II and costimulatory molecules on macrophages (Eskdale et al. 1997).

白介素10（IL10）基因定位于染色体1q31-32区域。该基因编码同名的蛋白质，该蛋白质作为多效性细胞因子，主要由单核细胞表达，在一定程度上亦由淋巴细胞表达。IL10可下调Th1细胞因子、MHC II类和巨噬细胞上的共刺激分子表达（Eskdale等，1997年）。