Regimens for rivaroxaban, warfarin, ximelagatran, DX-9065a and enoxaparin included in the model.

53 mg OD/BD doses (although not used in clinical studies) were simulated to double exposure (Cmean) of 20 mg OD/BD, taking into account the less than dose-proportional increase in exposure due to reduced absorption, observed at high doses [3], [26]. A control without any drugs was also run in the model. BD, twice daily; Cmax, maximum drug concentration; Cmean, average drug concentration; Ctrough, minimum drug concentration; INR, international normalized ratio; IV, intravenous; OD, once daily; s.c., subcutaneous.