Host response to Leishmania amazonensis and OPN role in immune responses. In vivo.

Transcript profiles as indicated in the ear pinna and draining lymph nodes (DLN) of NOD+/+ (WT) and NOD.opn-/- (KO) mice in response to L. amazonensis. 104 metacyclic promastigotes of parasites (LV79 strain) were inoculated in the ear dermis of the mice and transcript profiles were evaluated in the temporal windows spanning the early and expansion phase (EP-ExP) at Day40 p.i. and the parasite reduction phase (RP) at Day100 p.i. (see Fig 2). Mean fold changes for transcripts and standard deviations have been calculated in the opn KO mice by using as a calibrator the wild-type D40 p.i. value. Significant differences (p