Single-cell gene expression of virus-specific CD4 T cells in response to acute and chronic infection

Single-cell gene expression of GP66 CD4+ T cells was determined by scRNAseq after LCMV Armstrong and Clone 13 infection Overall design: C57Bl6 were infected with LCMV Armstrong or Clone 13. Spleen GP66+ CD4+ T cells were sorted 7 , 21 and 80 days post-infection and gene expression was determined by scRNAseq + scTCR