Dominant Intra-Individual Pattern of Nucleotides Coding for K64, K65 and K66 in 27 Subtype B and 18 Subtype C Isolates from Untreated Individuals: Association with presence of K65R as Determined by Ultra-Deep Pyrosequencing (UDPS)^*.

*The column “KKK Motif” indicates the Sanger sequence of the codons 65 to 67 in the plasma virus samples. The column “No. Isolates” indicates the number of individuals with the Sanger sequence shown in the “KKK Motif column”. The column “K65R (≥1.0%)” indicates the number of samples for which ≥1.0% of the reads had K65R. The range in proportions is shown in parentheses. The proportion of reads with K65R was determined by dividing the number of reads with K65R by the total number of sequencing reads encompassing codon 65. †This sample had a complex mixture of KKK nucleotide variants including AAA-AAG-AAA (the second-most common subtype C pattern) in 38% of reads, AAG-AAA-AAA (the most common subtype B pattern) in 7% of reads, and the uncommon pattern AAG-AAG-AAA in 50% of reads.