XPO1 enables adaptive regulation of mRNA export required for genotoxic stress tolerance in cancer cells

To determine how exposure to CHOP, Selinexor or their combination affects gene expression in DLBCL, we first established a patient-derived xenograft model of DLBCL. Next, mice were randomized to receive either vehicle, CHOP, Selinexor or their combination. Tumors were harvested at the end of treatment and gene expression profile analyzed by RNA-sequencing. Overall design: Three replicates per treatment arm (vehicle, CHOP, Selinexor, CHOP + selinexor) were sequenced.