INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1
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INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1 Descriptor: (3R,6R,7S,8E,11S,12R,22S)-6'-chloro-7-methoxy-11,12-dimethyl-13,13-dioxo-spiro[20-oxa-13-gamma6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene-22,1'-tetralin]-15-one, Fab Heavy Chain, Fab Light Chain, ... Authors: Hargreaves, D. Deposit date: 2022-08-26 Release date: 2023-05-24 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1. Proc.Natl.Acad.Sci.USA, 120, 2023
与化合物1结合的诱导髓系白血病细胞分化蛋白抗原结合片段（Fab）复合物 描述符：(3R,6R,7S,8E,11S,12R,22S)-6'-氯-7-甲氧基-11,12-二甲基-13,13-二氧代-螺[20-氧杂-13-γ6-硫杂-1,14-二氮杂四环[14.7.2.0³,⁶.0¹⁹,²⁴]二十五碳-8,16(25),17,19(24)-四烯-22,1'-四氢萘]-15-酮、Fab重链、Fab轻链等 作者：哈格里夫斯（Hargreaves, D.） 沉积日期：2022-08-26 发布日期：2023-05-24 最后修改日期：2024-11-13 检测方法：X射线衍射（分辨率1.99 Å） 引用文献：《刚性蛋白-蛋白相互作用抑制剂的设计可靶向不可成药靶点Mcl-1》，《美国国家科学院院刊（Proc. Natl. Acad. Sci. USA）》，2023年，第120卷
