α‑Acyl-α-diazoacetates in Transition-Metal-Free β‑Lactam Synthesis
收藏Figshare2019-08-21 更新2026-04-29 收录
下载链接：
https://figshare.com/articles/dataset/_Acyl-_-diazoacetates_in_Transition-Metal-Free_Lactam_Synthesis/9759989
下载链接
链接失效反馈官方服务：
资源简介：
Thermally promoted reaction of α-acyl-α-diazoacetates with imines has been investigated. The transformation, earlier reported predominantly under transition metal catalyzed conditions, delivers α-alkoxycarbonyl-substituted β-lactams with outstanding diastereoselectivity. DFT calculations performed in order to evaluate energetically feasible reaction pathways revealed the intermediacy of 1,3-oxazin-4-one intermediates hitherto never implicated in the Staudinger synthesis of β-lactams.
创建时间：
2019-08-21
