Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy

NIAID Data Ecosystem2026-03-10 收录

线粒体心肌病

心脏转录组分析

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA376146 数据链接链接失效反馈

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ANT1 inactivated and WT Mouse Heart tissue RNA-Seq

创建时间：

2017-02-21

heart Raw sequence reads

心脏转录组分析

RNA-seq差异表达分析

After obtaining the raw sequencing data (Raw Data), it is first necessary to filter the data, remove the adapter sequence, and process the low-quality reads.The sequencing quality was then evaluated t

NIAID Data Ecosystem80

Phospholamban Antisense Oligonucleotides Improve Cardiac Function in Murine Cardiomyopathy

心肌病基因治疗

心脏转录组分析

Heart failure (HF) is a major cause of morbidity and mortality worldwide, but therapeutic intervention remains limited despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathop

NIAID Data Ecosystem70

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondiral cardiomyopathy

线粒体心肌病

代谢重编程

The goal of this study was to analyze the molecular changes that occur over the time course of disease in a mutant CHCHD10-related mouse model of primary mitochondrial cardiomyopathy. Libraries were s

Alliance of Genome Resources20

Clinical trial dataset supporting: Mavodelpar in Patients with Primary Mitochondrial Myopathy: A Phase 1 Trial

药物临床试验

线粒体心肌病

This dataset includes the clinical trial dataset and clinical trial documentation supporting: Mavodelpar in Patients with Primary Mitochondrial Myopathy: A Phase 1 Trial (Stefanetti et al.)DetailsAuth

Figshare2026-02-27 更新70

Genome-wide profiling of gene expression of normal and Tbx20 knockout adult mouse whole heart. Mus musculus

Tbx20心脏功能

心脏转录组分析

Tbx20 is a transcription factor important for heart development. To assess the role of Tbx20 in the adult heart, we generated a conditional knockout for this gene, specifically in cardiomyocytes. We p

NIAID Data Ecosystem50

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy

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