Changes in poisoning deaths involving co-proxamol, other analgesics, and all drugs, in England and Wales, 1998–2010, associated with the Committee on Safety of Medicines (CSM) announcement in January 2005.

aUsing interrupted time-series segmented regression analysis where the intervention point is taken as the end of 2004 (the CSM announcement on the withdrawal of co-proxamol, January 2005).bEstimated for the midpoint quarter of 2005–2010. See Text S1 for method, equation (2) or (3).cAbsolute difference of estimated number with CSM announcement and estimated number without CSM announcement, taken at the mid-point of the post-intervention period, see Text S1 equation (4).d95% CIs taken from Stata results or calculated according to Zhang et al. [38].eOther analgesics include: co-codamol, codeine, co-dydramol, dihydrocodeine, NSAIDS, paracetamol, and tramadol.

采用中断时间序列分段回归分析，以2004年年末（2005年1月CSM关于双氢可待因撤回的公告）作为干预点。对2005至2010年中点季度进行估算。详见文本S1，方法及公式（2）或（3）。计算值与CSM公告的绝对差值，取干预期中点，详见文本S1公式（4）。95%置信区间根据Stata结果或张等人[38]的计算方法得出。其他镇痛药包括：可待因对乙酰氨基酚、吗啡、可待因多乙酰吗啡、二氢可待因、非甾体抗炎药、对乙酰氨基酚和曲马多。