Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke

<b>Aim: </b>The study was designed to develop and analyze curcumin nanoparticles. <b>Methods: </b>Curcumin nanoparticles were formulated and evaluated. Their efficacy in protecting against brain damage was investigated in a rat model of ischemic stroke, considering motor function, muscle strength and antioxidant enzyme activity. <b>Results: </b>Curcumin nanoparticles displayed a zeta potential of - 55 <b>± </b>13.5 mV and an average particle size of 51.40 <b>± </b>21.70 nm. In ischemic stroke rat models, curcumin nanoparticle treatment significantly improved motor functions, and muscle strength and increased the activities of antioxidant enzymes like glutathione peroxidase, glutathione, glutathione S-transferase, superoxide dismutase and catalase, reducing oxidative stress and inflammation. <b>Conclusion: </b>Curcumin nanoparticles showed significant neuroprotective effects in ischemic stroke models.