Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study (nuMoM2b Heart Health Study)

Participants from study sites that recruited during the original study funded by NICHD of pregnant people, called nuMoM2b, participated in this study. The nuMoM2b-HHS1 was a prospective observational follow-up study of the [nuMoM2b](https://www.nichd.nih.gov/research/supported/nuMoM2b) cohort consisting of interval contacts via phone or web every 6 months to about a year, and an in-person visit 2 to 7 years after the end of the nuMoM2b pregnancy including: - Demographics - Self-administered questionnaires - Clinical measurements - Lab results - An in-home sleep breathing assessment for the subset of participants with at least one valid sleep breathing assessment during nuMoM2b - Abstraction of medical records for pregnancies subsequent to nuMoM2b involving self-reported adverse pregnancy outcomes or multiple births - Abstraction of medical records of selected cardiovascular risk-related events or procedures reported by participants. The study capitalized on the rich and unique data prospectively collected during nuMoM2b (biomarkers, uterine artery Doppler studies, fetal growth, psychosocial determinants, sleep, and blood pressure) and rigorous definitions of adverse pregnancy outcomes. These data are stored in the NICHD repository DASH (https://dash.nichd.nih.gov/study/226675). A total of 8,838 nuMoM2b participants were targeted for contact during nuMoM2b-HHS and 7,872 participants were reached, of whom 7,003 completed one or more interval contacts. Of these, 5,206 agreed to the visit, and 4,508 attended an in-person visit.本研究的参与者均来自由美国国立儿童健康与人类发育研究所（National Institute of Child Health and Human Development, NICHD）资助的原始妊娠人群研究nuMoM2b的招募站点。nuMoM2b-HHS1是针对nuMoM2b队列的前瞻性观察性随访研究，具体研究方案为：通过电话或网络每6个月开展1次间隔性随访，持续时长约1年；并在nuMoM2b妊娠研究结束后2至7年，开展1次线下访视，访视内容包括： - 人口统计学信息采集、自填问卷、临床指标测量、实验室检测结果获取 - 针对在nuMoM2b研究期间完成至少1次有效睡眠呼吸评估的参与者亚组，增设家庭睡眠呼吸评估 - 针对nuMoM2b研究后报告不良妊娠结局或多胎妊娠的参与者，提取其后续妊娠的医疗记录信息 - 提取参与者报告的与心血管风险相关的选定事件或操作的医疗记录信息 本研究充分利用了nuMoM2b研究期间前瞻性收集的丰富且独特的研究数据，包括生物标志物、子宫动脉多普勒超声检查、胎儿生长情况、社会心理决定因素、睡眠状况及血压数据，并采用了不良妊娠结局的严格定义标准。相关研究数据存储于NICHD的DASH数据库（https://dash.nichd.nih.gov/study/226675）。 nuMoM2b-HHS1研究共计划联系8838名nuMoM2b参与者，最终成功联系到7872名，其中7003名完成了至少1次间隔性随访。在完成间隔随访的参与者中，5206名同意参与线下访视，最终4508名完成了全部线下访视流程。