Anti-anginal Efficacy of Ticagrelor in Coronary Slow Flow

The CSFP is an angiographic finding characterised by the delayed passage of contrast through the coronary arteries, despite the absence of obstructive coronary artery disease (defined as less than 50% narrowing of the vessel lumen). Ticagrelor may serve as an effective anti-anginal therapy for these patients by increasing adenosine levels, which could alleviate coronary microvascular dysfunction and its associated angina due to its vasodilatory properties.This study is designed as a double-­blind, placebo controlled, crossover study, to assess the effect of ticagrelor 90mg bd on angina frequency in patients with the Coronary Slow Flow Phenomenon (CSFP) who experience angina at least 3 times/week.This asset includes data evaluating the anti-anginal efficacy of a 4-week ticagrelor therapy regimen in 20 CSFP patients with refractory angina. The mean age of patients 61.5 ± 10.5 years and 40% were women. Additionally, the asset includes the trial primary endpoint, which was the frequency of angina episodes, recorded using an angina diary. Secondary endpoints include the duration and severity of angina episodes, consumption of short-acting nitrates, and health status evaluations using the Seattle Angina Questionnaire (SAQ) and the Short Form-36 (SF-36) indices.Results from the data asset are publicly available in an open-access publication: https://www.mdpi.com/2077-0383/13/17/5235Requests in relation to this data asset should be made to the corresponding author. The data are not publicly available due to privacy and ethical restrictions.冠状动脉慢血流现象（Coronary Slow Flow Phenomenon，CSFP）是一种血管造影表现，其特征为尽管不存在阻塞性冠状动脉疾病（定义为血管腔狭窄程度＜50%），但造影剂在冠状动脉内的通过过程出现延迟。替格瑞洛（ticagrelor）可作为此类患者的有效抗心绞痛治疗手段：它可通过提升腺苷水平发挥血管舒张作用，从而改善冠状动脉微血管功能障碍及其伴随的心绞痛症状。 本研究为双盲、安慰剂对照交叉试验，旨在评估90mg每日两次的替格瑞洛给药方案对每周至少发作3次心绞痛的CSFP患者心绞痛发作频率的影响。 本数据集包含20例难治性心绞痛CSFP患者接受4周替格瑞洛治疗方案后的抗心绞痛疗效评估数据。入组患者的平均年龄为61.5±10.5岁，其中女性占比40%。此外，本数据集还涵盖了试验的主要终点——通过心绞痛日记记录的心绞痛发作频率；次要终点则包括心绞痛发作的持续时间与严重程度、短效硝酸酯类药物的使用量，以及采用西雅图心绞痛问卷（Seattle Angina Questionnaire，SAQ）和简明健康调查问卷36项版（Short Form-36，SF-36）进行的健康状况评估。 该数据集的研究结果已发表于开源期刊，公开链接为https://www.mdpi.com/2077-0383/13/17/5235。如需获取本数据集的相关请求，请联系通讯作者。由于存在隐私与伦理限制，本数据集未直接公开。