Model parameters, definitions and values estimated from literature.

*The 25 parameters used for sensitivity analysis are indicated by their ranges of values. Values in parentheses are used to generate other model results.
†Diffusion coefficients of the soluble species in granuloma were estimated in line with estimates for diffusible factors of similar molecular weight in tumors [88], [89].
‡Consistent with extracellular volume fraction estimated for multi –cellular tumor spheroids [90], [91].
§Half mean distance between granulomas were calculated from the granuloma density assessed for 2D sections of the lung tissue [92], [93] and assumed to be consistent in 3D.