Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.
收藏PubMed Central1996-09-03 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC38518/
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资源简介：
Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-09-03
