Effect of aprotinin on hemodynamics and LV remodeling at 2 day and 4 wk rats.

Values are expressed as mean±SEM. In each group, values in parentheses represent n. *P0.05 vs. age-matched shams. †P0.05 vs. ACF. ACF: aortocaval fistula; Apr: aprotinin; HR: heart rate; MAP: mean arterial pressure; LVEDP: LV end-diastolic pressure; LV+dP/dt: LV pressure derivative maximum; LV-dP/dt: LV pressure derivative minimum. LVEDD: LV end-diastolic dimension; LVESD: LV end-systolic dimension; LVEDD/PW: LV end-diastolic dimension to posterior wall thickness ratio; FS: fractional shortening; EF: ejection fraction; VCFr: velocity of circumferential fiber shortening; LVED-WS: LV end-diastolic wall stress; LVES-WS: LV end-systolic wall stress; Coll Vol (%): interstitial collagen volume percent.