Versatile Coordination Behavior of Salicylaldehydethiosemicarbazone in Ruthenium(II) Carbonyl Complexes: Synthesis, Spectral, X‑ray, Electrochemistry, DNA Binding, Cytotoxicity, and Cellular Uptake Studies
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https://figshare.com/articles/dataset/Versatile_Coordination_Behavior_of_Salicylaldehydethiosemicarbazone_in_Ruthenium_II_Carbonyl_Complexes_Synthesis_Spectral_X_ray_Electrochemistry_DNA_Binding_Cytotoxicity_and_Cellular_Uptake_Studies/2461855
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资源简介：
The reaction of salicylaldehydethiosemicarbazone, [H2-(Sal-tsc)], with an equimolar amount of [RuHCl(CO)(PPh3)3] has afforded two complexes, namely [Ru(H-Sal-tsc)(CO)Cl(PPh3)2] (1) and [Ru(Sal-tsc)(CO)(PPh3)2] (2), in one pot. The new complexes
were separated and characterized by elemental analyses, various spectroscopic
techniques (NMR, UV–vis, IR), X-ray crystallography, and cyclic
voltammetry. In complex 1, the ligand coordinated in
a bidentate monobasic fashion by forming an unusual strained NS four-membered
ring in 32% yield. However, in 2, the ligand coordinated
in a tridentate dibasic fashion by forming ONS five- and six-membered
rings in 51% yield. Comparative biological studies such as DNA binding,
cytotoxicity (MTT, LDH, and NO), and cellular uptake studies have
been carried out for new ruthenium(II) complexes (1 and 2). From the DNA binding studies, it is inferred that the
complex 1 exhibited electrostatic binding and 2 exhibited intercalative binding modes. On comparison of the cytotoxicity
of the complexes in human lung cancer cells (A549) and liver cancer
cells (HepG2), complex 2 exhibited better activity than 1; this may be due to the strong chelation and subsequent
electron delocalization in 2 increasing the lipophilic
character of the metal ion into cells.
创建时间：
2016-02-20
