Robust hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=de5993f71669b6a11c49befcb1d2f514
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资源简介：
The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. Although an intra-embryonic origin is supported, recent data suggest that a large fraction of adult blood derives from the yolk sac (YS). Investigating the origins of hematopoiesis before heartbeat onset (i.e. 5-7 somite pairs (sp)) is precluded by a lack of assays that can distinguish dHSC precursors in early embryos. Here, we report robust, multi-lineage and serially transplantable dHSC activity from cultured 2-7sp murine embryonic explants (Em-Ex). dHSC were undetectable in 2-7sp YS explants (YS-Ex). Our work supports a model in which the embryo, not the YS, is the major source of lifelong hematopoiesis.
提供机构：
st jude children's research hospital
创建时间：
2022-02-20
