GRA HPA Axis Supplementary Tables and Stats

We hypothesized that the chronic administration of the novel GR receptor modulator CORT113176 during chronic sleep restriction (SR) and opioid abstinence would reveal important effects on the HPA axis giving insight into mechanisms of the interaction of SR and opioid abstinence. We concluded that the response of the HPA axis to CORT113176 during SR and opioid abstinence is not predictable by sex or sleep state because it can act both as an antagonist and agonist in the brain and pituitary, and an agonist in the adrenal gland in a sexually dimorphic manner.