Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile

Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile Descriptor: (2R)-3-cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)propanenitrile, Heat shock protein HSP 90-alpha Authors: Musil, D, Lehmann, M, Graedler, U, Buchstaller, H.-P. Deposit date: 2012-03-30 Release date: 2012-06-27 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 Bioorg.Med.Chem.Lett., 22, 2012

本数据集对应复合物为与抑制剂3-环己基-2-(6-羟基-1H-吲唑-3-基)丙腈结合的热休克蛋白HSP 90-α（Heat shock protein HSP 90-alpha）N端结构域。描述项：(2R)-3-环己基-2-(6-羟基-1H-吲唑-3-基)丙腈，热休克蛋白HSP 90-α。作者：Musil, D、Lehmann, M、Graedler, U、Buchstaller, H.-P.。提交日期：2012-03-30，发布日期：2012-06-27，最后修改日期：2024-03-20。实验方法：X射线衍射（分辨率2.12埃）。引用文献：《基于片段筛选发现羟基吲唑甲酰胺类新型HSP 90小分子抑制剂》，Bioorg.Med.Chem.Lett.，2012年，第22卷。