Expression data from hiPSC derived WT and ISG15 KO endothelial cells stimulated with interferon-a and treated with itaconic acid, dimethyl itaconate, 4-octyl itaconate and ruxolitinib

Analysis of gene expression in WT and ISG15 KO endothelial cells, stimulated with IFNa and treated with Itaconic acid (IA), Dimethyl itaconate (DI), 4-octyl itaconate (4OI) and ruxolitinib (RUX) to investigate the effects of treatments on transcriptional response in the cells. WT and ISG15 KO endothelial cells were differentiated from hiPSCs. Endothelial cells were stimulated with interferon-a for 8 hours. Cells were then treated with itaconic acid, dimethyl itaconate, 4-octyl itaconate and ruxolitinib for 16 hours. RNA was extracted, and subjected to transcriptome profiling array Clariom™ S Assay, human.