Number of individuals exhibiting several genome-wide distributions of each epigenome marker.

Number of individuals of ADHH, ADLL, and ADHL exhibiting typical or untypical genome-wide distributions of H3K4me3 (a), H3K27ac (b), H3K27me3 (c), and CTCF (d). Number of individuals of ADHH, ADLL, and ADHL exhibiting first type (Typical 1), second type (Typical 2) or untypical genome-wide distributions of H3K4me3 (e). Number of individuals of NCI, MCI, and AD exhibiting Typical 1, Typical 2 or untypical genome-wide distributions of H3K4me3 (f). Number of individuals exhibiting each genome-wide epigenome status in each substage or stage was obtained from Fig 4 and 5, and S4 Fig in Supplementary File. P-values obtained using the Fisher’s exact test were 0.04328 (a), 0.193439 (b), 0.193439 (c), 0.285294 (d), 0.042163, and 0.428061 (f).