The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction

The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction Descriptor: 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide, E3 ubiquitin-protein ligase Mdm2 Authors: Kallen, J. Deposit date: 2012-01-31 Release date: 2012-05-02 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction. Bioorg.Med.Chem.Lett., 22, 2012

中央缬氨酸概念为一类新型非肽类P53-MDM2相互作用抑制剂提供了研发切入点。描述符：6-氯-3-[1-(4-氯苄基)-4-苯基-1H-咪唑-5-基]-N-[2-(吗啉-4-基)乙基]-1H-吲哚-2-甲酰胺，E3泛素蛋白连接酶Mdm2。作者：J·卡伦（Kallen, J.）。提交日期：2012-01-31。发布日期：2012-05-02。最后修改日期：2024-04-03。研究方法：X射线衍射（分辨率1.9 Å）。引用文献：《The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction》，刊载于Bioorg.Med.Chem.Lett.，2012年第22卷。