Synthetic circuit identifies subpopulations with sustained memory of DNA damage

ChEBI2012-03-02 更新2026-07-21 收录

合成生物学电路

DNA损伤

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-36210 数据链接链接失效反馈

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Synthetic circuit identifies subpopulations with sustained memory of DNA damage

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2012-03-02

A surge of DNA damage links transcriptional reprogramming and hematopoietic deficit in Fanconi anemia

范可尼贫血机制

DNA损伤

Impaired DNA crosslink repair leads to Fanconi anemia (FA), characterized by a unique manifestation of bone marrow failure and pancytopenia among diseases caused by DNA damage response defects. As a r

Mendeley Data2024-01-31 更新160

Figure 3_gH2AX IF-FISH

细胞生物学

DNA损伤

The data included here is used to report the finding that loss of SMCHD1 in shTRF2 depleted HeLa cells affects the tnumber of gH2AX foci at telomere. The data is part of figure 1B and C of the followi

Mendeley Data2024-01-31 更新80

Supplementary Material for: Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging

腺体衰老机制

DNA损伤

Background: Aging is a multifactorial process characterized by organ loss of function and degeneration, but the mechanisms involved remain elusive. We have shown recently that catecholamine metabolism

NIAID Data Ecosystem30

Figure 2d Representative Photographs

细胞生物学

DNA损伤

The file shows representative images that went into Fig. 2d: Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Wang J ,

DataCite Commons2020-08-27 更新90

Effect of DNA damage on ligand stimulated EGFR signaling pathways. Effect of DNA damage on ligand stimulated EGFR signaling pathways

EGFR信号通路

DNA损伤

We examined the cellular response of primary normal cells to EGFR stimulation under normal and DNA damage conditions. Overall design: Examining changes in the response to EGFR triggering in cells suff

NIAID Data Ecosystem80

Synthetic circuit identifies subpopulations with sustained memory of DNA damage

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