Integrated multilayer omics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart. Integrated multilayer omics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart

This study using a system biology approach of transcriptomics, proteomics and metabolomics, we elucidated the role of endogenous histidyl dipeptides on cellular pathways and myocardial metabolism. Our multi-omics approach for the first-time unravels the landscape of genetic, proteomic, and metabolic changes influenced by histidyl di peptides. Overall design: Gene expression comparison of mice with and without Carns transgenic. 8 samples were grouped into 2, WT and TG. Each group include 4 replicates.