Enantioselective Total Synthesis and Assignment of the Absolute Configuration of the Furo[3,2‑<i>a</i>]carbazole Alkaloid Furoclausine‑B

We describe the first enantioselective total synthesis and the assignment of the absolute configuration of the furo­[3,2-a]­carbazole alkaloid furoclausine-B. As key steps for our approach we used a palladium­(II)-catalyzed double C–H-bond activation for the construction of the carbazole framework, a Shi epoxidation, and an intramolecular opening of the epoxide for annulation of the dihydrofuran moiety.