We examined the DNA damage response of bacterium E. coli using the replication inhibitor azidothyimdine (AZT), and RNA-Seq analysis. We confirm the induction of classic SOS loci by AZT and identify se

NIAID Data Ecosystem30

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site

DNA损伤修复

结构生物学

Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-

Protein Data Bank Japan2023-10-11 更新40

Catalytically inactive (E3Q) MutM crosslinked to oxoG:C containing DNA CC1

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