DISCOVERY and GENERALIZATION.

Evidence for qualitative (cases versus controls) associations for 5 loci (10 SNPs) under a log-additive genetic model. Effect sizes as point estimators and 95% confidence intervals (95% CI), p-values (two-sided) and combined p-values are presented; all samples are described in detail in Text S1.
aposition and stranding according to dbSNP BUILD 129; Map to Genome Build 36.3;
b(obesity) effect risk alleles as derived from the paediatric extreme obesity GWAS meta-analysis;
cfrom all population-based children and adolescents samples (GINI/LISA and Berlin School Girls sample with a BMI quantile < age- and gender-matched median) or adults (KORA with BMI <25 kg/m2); all exact two-sided p-values of HWE test >0.01;
dcombined p-values by Fischer combination rule;
ers473034 (TNKS/MSRA) and rs1421085 (FTO) had genome-wide significant p-values of 2.77×10−8 and 2.99×10−8 in the paediatric extreme obesity GWAS meta-analysis but proxies were chosen for the follow-up;
fresults for rs17700144 (MC4R) are based on the proxy marker rs10871777.